MD Cryo-EM Vitrification Screen
Vitrification screen for optimisation of cryo-EM sample preparation. Designed to help mitigate air–water interface adsorption, orientation bias, and aggregation.
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Product Description
The MD Cryo-EM Vitrification Screen (MD1-911) is a rationally designed additive screen of 19 different conditions aimed at improving vitrification outcomes in single-particle cryo-electron microscopy workflows. It systematically addresses the most common sample preparation bottlenecks, including air–water interface (AWI) adsorption, preferred orientation, aggregation, and uneven ice - by providing a diverse set of validated detergents and surfactants for buffer and additive screening.
Developed by Molecular Dimensions in collaboration with Anatrace, this screen brings together over 60 years of combined expertise in detergents, surfactants, and cryo-EM sample optimisation.
- Targets adsorption, orientation bias, particle distribution, and ice thickness
- Wide chemical space: detergents, amphipols, fluorinated surfactants
- Built on peer-reviewed literature and real-world cryo-EM successes
- Compatible with standard vitrification systems (Vitrobot, Chameleon, automatic plunge-freezers)
UOM 19 x 100ul