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Agar Scientific

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Gold conjugates

Colloidal gold was first introduced as a cytochemical marker for TEM in 1971 by Faulk and Taylor*, and has become the universally accepted label of choice for electron microscope immunocytochemistry applications and detection of cellular and subcellular macromolecules. It is now a well established technique. Gold labels combine the benefit of unequivocal identification of antigens together with high resolution localisation. The wide choice of gold particle sizes available for labelling at different working magnifications, together with its quantitative facility, also make gold labelling a very flexible tool. One of the major advantages of colloidal gold for electron microscopy is its high electron density, offering easy detection. Procedures for using gold reagents are now well established, and these techniques have been proven to be simple, efficient and economical, as well as non-hazardous.

For 2nm and 5nm gold conjugates a combination of gold labelling with silver enhancing will yield larger size particles with high labelling intensity.

For Light Microscopy the smaller sizes are recommended (2 + 5nm) in conjunction with silver enhancing.

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11 Item(s)

  1. Gold conjugates for LM

    Gold conjugates for LM

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    Light microscope immunocytochemistry with gold conjugates follows similar principles to the well established indirect labelling methods using peroxidase labelled secondary antibodies, but offers several advantages.
  2. Gold conjugates for in situ hybridisation

    Gold conjugates for in situ hybridisation

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    Specific DNA or RNA fragments may be readily identified within cells afterin situ hybridisation with appropriate DNA/RNA probes.
  3. Gold conjugates for blotted proteins

    Gold conjugates for blotted proteins

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    Blotting techniques have been established for a number of years, and the use of immunogold conjugates provides a safe, sensitive and economical alternative to traditional labels.
  4. Unconjugated gold colloids

    Unconjugated gold colloids

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    Nanometre sized gold particles of uniform shape and size are invaluable tools in nanotechnology, eg. assembled arrays, light scattering etc.
  5. Unconjugated silver colloids

    Unconjugated silver colloids

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    Nanometre sized silver particles of uniform shape and size are invaluable tools in nanotechnology, eg. assembled arrays, light scattering etc.
  6. Silver enhancing kits

    Silver enhancing kits

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    These kits offer ease of use and sensitivity for the amplification of immunogold labels in electron and light microscopy and blotting applications.
  7. Blocking reagents

    Blocking reagents

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    Non-specific labelling of specimens can occur during immunolabelling procedures.
  8. Protogold. 500ml

    Protogold. 500ml

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    PROTOGOLD® colloidal gold solution has been specifically developed to give intense staining of proteins blotted onto membranes by dot blots or electrophoretic gels.

    Part no: AGR14084

  9. Specialist gold and silver nanoparticles
  10. Biomount, 100ml

    Biomount, 100ml

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    Biomount mounting medium reduces fading of immunogold/silver signals in sections on glass slides and can be used with both resin and wax embedded tissue sections.

    Part no: AGR1354

  11. Goat Anti Rat Igg 10nm 0.25ml

    Goat Anti Rat Igg 10nm 0.25ml

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    Part no: AGR14183-1

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11 Item(s)